Amphetamine is known to inhibit monoamine oxidase, whereas the power of amphetamine and its metabolites to inhibit various P450 isozymes and also other enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes indicate slight inhibition of CYP2D6 by amphetamine and insignificant inhibition of CYP1A2, 2D6, and 3A4 by one